The Israeli military has announced it was launching a new wave of attacks against Iran as it confirms its first casualties.

The Israeli Defence Forces says the strikes on the Iranian capital Tehran are targeting "military infrastructure" reports Associated Press.

US-Israeli strikes have killed more than 1000 people in Iran so far.

The Israeli military also said two troops were wounded yesterday by anti-tank fire while operating in southern Lebanon.

Hezbollah says its fighters attacked Israeli troops advancing toward the village of Khiyam and released video showing a missile striking a tank.

Foreign Minister Penny Wong has just warned the conflict between the US-Israel and Iran was spreading, after an Iranian ballistic missile was fired towards Turkey overnight.

"I am concerned that the conflict is spreading so much," she told Today this morning.

"I am concerned, for example, that Iran is now seeking to strike Turkey, which is a NATO member.

"Now, the more this conflict spreads, the harder it will be for peace and stability to be resumed … at some point, there has to be a return to diplomacy and dialogue for there to be stability."

The US is not ruling out it could have been responsible for the air attack on a girls primary school in southern Iran that reportedly killed more than 100 people.

Leavitt has been pressed about whether US military personnel were involved on the attack in Minab.

"Not that we know of," she said.

Leavitt also said the US armed forces "does not target civilians."

Earlier, US Defence Secretary Pete Hegseth said the Pentagon had launched an investigation into the strike on the school.

Leavitt has given details of the four US military objectives in the conflict.

She says they are: destroy the Iranian regime's ballistic missile program; "annihilate" Iran's naval presence in the region; dismantle Iran's terrorist proxies, which have been responsible for attacks on US and coalition forces; and prevent Iran from further pursuing a nuclear weapon.

Leavitt also said changing the Iranian leadership was not a main goal.

"Obviously, as the president has said numerous times, do we want to see Iran being led by a rogue terrorist regime? No, of course, not," she said.

The Trump administration is maintaining Iran's main goal was building a nuclear weapon with which to threaten the United States.

White House press secretary Karoline Leavitt is giving a media briefing and says Iran "refused to say yes to peace, and their refusal made clear that their number one priority was building a nuclear weapon".

"Iran rejected the path of peace because the terrorists in charge of this regime wanted to build nuclear weapons to use against Americans and our allies," she said.

The Iranian government has previously declared its nuclear program was about civil energy and it had no goals to develop a nuclear weapon.

Leavitt also says Trump ordered the military strikes off a "good feeling" that the Iranian regime was planning to attack the US.

"The president was faced with a choice: does the United States of American use our military and our capabilities to strike first to take out this threat that has been threatening our country and our people for 47 years, or is he going to - as commander in chief – sit back and watch as the rogue Iranian regime attacks our people in the region," she said.

The US has sunk an Iranian warship by firing a torpedo from a US Navy fast-attack submarine.

It's the first time the US has used a torpedo to strike an enemy target since World War II.

A US official, who was not authorised to comment publicly and spoke on condition of anonymity, confirmed the Iranian ship was the Dena.

The sinking of the Iranian warship in the Indian Ocean illustrates how the US military operation against Iran is stretching far beyond the Islamic Republic's borders.

Trump has said that one of the U.S. military's main objectives in the campaign is to wipe out its Navy.

The United States and Israel hit Iran's capital and other cities in multiple airstrikes overnight, as the war with Iran entered its fifth day. Israel targeted the Iranian leadership and security forces as the Islamic Republic responded with missile barrages and drone attacks on Israel and across the region.

Tehran residents woke to dawn blasts, and Iranian state television showed the ruins of buildings in the centre of the capital. The Shiite seminary city of Qom and multiple other cities were also targeted.

With fighter jets roaring overhead, those still in Tehran looked anxiously to the skies. One man, who ran a clothing shop, said he didn't know what to do.

In case you missed it last night, there were joyful reunions at Sydney Airport as the first commercial flight out of Dubai arrived back in Australia, bringing home dozens who had been stranded for days as war waged in the Middle East.

"It has been quite nerve wracking, quite stressful, and very worrying," NSW mum Sheree, who drove three hours to greet her son, told 9News reporter Madi Scott.

"It was very scary on the ground for him, they weren't allowed out of their motels because of falling shrapnel from the intercepted drones and bombs, and he was just quite stressed out."

Sheree's son had been on his way to Rome but never made it, becoming stranded in Dubai when the war broke out.